ZLN 024 hydrochloride

SKU: orb1303144

Description

ZLN 024 hydrochloride is an allosteric activator of AMPK. It stimulates truncated, inactive α1 subunits (1-394 and 1-335) but not the shorter α1 (1-312) construct. This small molecule is used in vitro to study AMPK signaling mechanisms in metabolic and aging-related research.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 1883548-91-1
• MW: 361.68
• Purity: 98.54% (May vary between batches)
• Formula: C₁₃H₁₄BrClN₂OS
• SMILES: Cl.Cc1ccc(OCCSc2ncccn2)c(Br)c1
• Target: AMPK
• Solubility: DMSO:45 mg/mL (124.42 mM);H2O:< 0.1 mg/mL (insoluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.53 mM)

Bioactivity

• Target IC50:
  AMPK α2β1γ1:0.95 μM (EC50)|AMPK α1β2γ1:1.1 µM (EC50)|AMPK α1β1γ1:0.42 μM (EC50)|AMPK α2β2γ1:0.13 μM (EC50)
• In Vivo:
  In C57BKS db/db mice, ZLN 024 hydrochloride(15 mg/kg/day; oral) improves glucose tolerance after 4 weeks of treatment. ZLN 024 hydrochloride reduces the fasting blood glucose by 15%. Liver tissue weight, triacylglycerol and the total cholesterol content a
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• In Vitro:
  ZLN 024 hydrochloride increases the activity of α1β1γ1 by 1.5-fold and has an EC50 of 0.42 µM, and it increases the activity of α2β1γ1 by 1.7-fold with an EC50 of 0.95 µM. ZLN 024 hydrochloride also directly activates recombinant AMPK α1β2γ1, by 1.7-fold with an EC50 of 1.1 µM; and AMPK α2β2γ1, by 1.6-fold with an EC50 of 0.13 µM. ZLN 024 hydrochloride directly activates recombinant AMPK α1β1γ1 and its homolog α2β1γ1 in a concentration-dependent manner.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMPK α1β2γ1, AMPK α2β1γ1, AMPK α2β2γ1, AMPK α1β1γ1, AMP-activated protein kinase, AMPK, inhibit, Inhibitor, ZLN 024 Hydrochloride, ZLN024, ZLN-024, ZLN024 Hydrochloride, ZLN-024 Hydrochloride, ZLN 024, ZLN 024 hydrochloride

Compound Identifiers

PubChem CID

91654626