ZLMT-72

SKU: orb3174061

Description

ZLMT-72 is an orally active dual inhibitor of CDK2 and CDK9, with IC50 values of 0.741 nM and 1.03 nM, respectively. It shows excellent selectivity in kinase profiling and cholinesterase inhibition activity assays. ZLMT-72 exhibits significant antiproliferative effects on colorectal cancer (CRC) cell line HCT116 (GI50 < 0.1 nM). This compound induces apoptosis by inhibiting the phosphorylation of retinoblastoma protein and RNA polymerase II, leading to the downregulation of anti-apoptotic proteins (Mcl-1 and XIAP). ZLMT-72 is suitable for colorectal cancer (CRC) research.

Research Area

Cell Biology, Molecular Biology

Key Properties

• Target: CDK,IAP,Bcl-2 Family,Apoptosis,DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CDK,IAP,Bcl-2 Family,Apoptosis,DNA/RNA Synthesis