ZK824190

SKU: orb1308915

Description

ZK824190 is a selective, orally bioavailable small molecule inhibitor of urokinase plasminogen activator (uPA), demonstrating selectivity over tissue-type plasminogen activator and plasmin. It is a research tool for studying uPA's role in cancer cell invasion, metastasis, and angiogenesis in both in vitro and in vivo models.

Research Area

Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 2254001-81-3
• MW: 414.4
• Purity: 98.84% (May vary between batches)
• Formula: C₂₂H₂₀F₂N₂O₄
• SMILES: O(C=1C=C(C=CC1)C2=CC(CN)=CC=C2)C=3N=C(O[C@@H](C(O)=O)CC)C(F)=CC3F
• Target: PAI-1,Serine Protease
• Solubility: DMSO:12 mg/mL (28.96 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.83 mM)

Bioactivity

• Target IC50:
  Plasmin:1850 nM |uPA:237 nM |TPA:1600 nM
• In Vivo:
  In rats with experimental autoimmune encephalomyelitis (EAE) model, ZK824190 (2 mg/kg; p.o.) exhibited a relatively high oral availability(F = 55%; Cmax= 0.64 g/mL and AUC = 2.2 h*g/mL) and a moderate half time of 2.8 h.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, multiple sclerosis, PAI-1, Inhibitor, Serine proteases, Serine Protease, Serine, Serine endopeptidases, Ser/Thr Protease, Threonine proteases, SerineProtease, Plasminogen activator inhibitor-1, Plasmin, plasminogen, ZK824190, ZK-824190, ZK 824190, protease, tPA, uPA, Urokinase

Compound Identifiers

PubChem CID

69496744