Ziyuglycoside II

SKU: orb1222331

Description

Ziyuglycoside II has anti-inflammation and antioxidation properties. Ziyuglycoside II has antibiosis, and homeostasis properties. Ziyuglycoside II has anticancer, and antitumor properties against gastric cancer and breast cancer cells, by cell cycle arrest and cell apoptosis.

Key Properties

• CAS Number: 35286-59-0
• MW: 604.82
• Purity: >98% (HPLC)
• Formula: C₃₅H₅₆O₈
• SMILES: CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)OC6C(C(C(CO6)O)O)O)C)C)C2C1(C)O)C)C(=O)O
• Target: GluR
• Solubility: In Vitro: DMSO : 50 mg/mL (82.67 mM)

Bioactivity

• In Vitro:
  Cell Viability Assay Cell line: MDA-MB-435 cells. Concentration: 10, 20, 30, 40, 50, 60 μM. Incubation time: 24 hours and 48 hours. Result: The IC50 at 24 h and 48 h was 5.92 μM and 4.74 μM, respectively. Cell Cycle Analysis Cell line: MDA-MB-435 cells. Concentration: 5, 10, 25 μM. Incubation time: 24 hours. Result: Induced G0/G1 and S phase arrest. Apoptosis Analysis Cell line: MDA-MB-435 cells. Concentration: 5, 10, 25 μM. Incubation time: 24 hours. Result: The apoptotic rate was significantly increased in comparison to that of the control. Western blot analysis. Cell line: MDA-MB-435 cells. Concentration: 5, 10, 25 μM. Incubation time: 24 hours. Result: Treatment resulted in increased expressions of both p53 and p21.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GluR