Ziprasidone hydrochloride monohydrate

SKU: orb1311004

Description

Ziprasidone hydrochloride monohydrate (CP 88059) is a combined serotonin and dopamine receptor antagonist with demonstrated antipsychotic activity. It is widely used in neuroscience research for investigating schizophrenia mechanisms and has been applied in both in vitro receptor binding assays and in vivo behavioral studies.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 138982-67-9
• MW: 467.12
• Purity: 99.95% (May vary between batches)
• Formula: C₂₁H₂₁ClN₄OS·HCl·H₂O
• SMILES: O.Cl.Clc1cc2NC(=O)Cc2cc1CCN1CCN(CC1)c1nsc2ccccc12
• Target: Dopamine Receptor,Norepinephrine,Adrenergic Receptor,Histamine Receptor,5-HT Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.14 mM);DMSO:4.67 mg/mL (10 mM)

Bioactivity

• Target IC50:
  D2 receptor (rat):4.8 nM|5-HT1A receptor (rat):3.4 nM|5-HT2A:0.42 nM|5-HT1A receptor (human):2.5 nM
• In Vivo:
  Ziprasidone blocked wild-type hERG currents in a voltage- and concentration-dependent manner in stably transfected HEK-293 cells with an IC(50) of 120 nM.Ziprasidone exhibited minimal hERG Ziprasidone significantly increased the time constant of the slow response to hERG current deactivation (-50 mV). ziprasidone is a 5-HT(1A) receptor agonist, as well as a 5-HT(2A), 5-HT(2C) and 5-HT(1B/1D) receptor antagonist. Ziprasidone is similar to the antidepressant promethazine in inhibiting the neuronal uptake of 5-HT and norepinephrine.Ziprasidone exhibits high affinity for human 5-HT receptors and human dopamine D(2) receptors.
• In Vitro:
  Ziprasidone blocked wild-type hERG currents in a voltage- and concentration-dependent manner in stably transfected HEK-293 cells with an IC(50) of 120 nM.Ziprasidone exhibited minimal hERG Ziprasidone significantly increased the time constant of the slow response to hERG current deactivation (-50 mV). ziprasidone is a 5-HT(1A) receptor agonist, as well as a 5-HT(2A), 5-HT(2C) and 5-HT(1B/1D) receptor antagonist. Ziprasidone is similar to the antidepressant promethazine in inhibiting the neuronal uptake of 5-HT and norepinephrine.Ziprasidone exhibits high affinity for human 5-HT receptors and human dopamine D(2) receptors.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ziprasidone hydrochloride, Ziprasidone Hydrochloride, Ziprasidone hydrochloride monohydrate, Ziprasidone hydrochloride Monohydrate, serotonin, Serotonin Receptor, α2A-adrenergic receptor, α1A-adrenergic receptor, 5-HT6, 5-HT7, 5HT Receptor, 5-hydroxytryptamine Receptor, 5HTReceptor, AdrenergicReceptor, Adrenergic Receptor, 5-HT2C, 5-HT1D, 5-HT1B, 5-HT1A, 5-HT2A, 5-HT transporter, 5-HT Receptor, antipsychotic agent, Dopamine, Dopamine Receptor, DopamineReceptor, D1, D3, D2, CP88059, CP-88059, CP 88059, CP 88059 hydrochloride, norepinephrine transporter (NET), inhibit, Inhibitor, Histamine Receptor, HistamineReceptor, HEK-293, H1 receptor

Compound Identifiers

PubChem CID

60853