ZIP14-IN-1

SKU: orb3172905

Description

ZIP14-IN-1 is a selective inhibitor of ZIP14. It can significantly inhibit the activity of ZIP14, but has no significant effect on ZIP8 (SLC39A8). ZIP14-IN-1 can effectively block the uptake of various divalent metal ions including zinc, iron, manganese and cadmium mediated by ZIP14. Its mechanism of action is to bind to the binding pocket formed at the dimer interface of ZIP14, thereby interfering with the metal ion transport pathway. In addition, ZIP14-IN-1 can reduce the levels of reactive oxygen species (ROS) and lipid peroxidation, alleviate metal-induced cytotoxicity, and can be used in related research on cancer cachexia .

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 1048-17-5
• MW: 335.44
• Purity: 99.11% (May vary between batches)
• Formula: C₂₁H₂₅N₃O
• SMILES: O=C1NCN(C=2C=CC=CC2)C13CCN(CCC=4C=CC=CC4)CC3
• Target: ROS

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ROS