Zingerone

SKU: orb1300526

Description

Zingerone, a natural compound from ginger, exhibits significant anti-inflammatory and antioxidant properties by modulating NF-κB signaling. It has demonstrated anti-tumor and anti-mitotic activity in neuroblastoma cell studies and shows therapeutic potential in animal models of diabetes and inflammatory diseases.

Research Area

Signal Transduction

Key Properties

• CAS Number: 122-48-5
• MW: 194.23
• Purity: 99.85% (May vary between batches)
• Formula: C₁₁H₁₄O₃
• SMILES: COc1cc(CCC(C)=O)ccc1O
• Target: NF-κB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.3 mM);Ethanol:36 mg/mL (185.35 mM);H2O:10 mg/mL (51.49 mM);DMSO:50 mg/mL (257.43 mM)

Bioactivity

• In Vitro:
  Zingeroneis similar in chemical structure to other flavor chemicals such as vanillin and eugenol. It is used as a flavor additive in spice oils and in perfumery to introduce spicy aromas. Fresh ginger does not contain vanillylacetone; cooking the ginger transforms gingerol, which is present, into Zingeronethrough a retro-aldol reaction. Zingeroneis likely the active constituent responsible for the antidiarrheal efficacy of ginger.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, NSC 15335, inhibit, NSC15335, NSC-15335, Nuclear factor-κB, Nuclear factor-kappaB, NF-κB, NFκB, NF-kB, NFkB, Gingerone, Vanillylacetone, Zingerone

Compound Identifiers

PubChem CID

31211