ZINC13466751

SKU: orb1308917

Description

This small molecule inhibitor potently disrupts the HIF-1α and von Hippel-Lindau protein interaction with an IC50 of 2.0 µM. It is a valuable research tool for studying hypoxia signaling pathways in oncology and cardiovascular disease, applicable in both cellular and biochemical assays.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research

Key Properties

• CAS Number: 117953-17-0
• MW: 363.41
• Purity: 99.94% (May vary between batches)
• Formula: C₂₀H₂₁N₅O₂
• SMILES: CC1=NN(C(=O)\C1=N/Nc1ccc(cc1)N1CCOCC1)c1ccccc1
• Target: HIF,HIF/HIF Prolyl-Hydroxylase
• Solubility: DMSO:7.5 mg/mL (20.64 mM)

Bioactivity

• Target IC50:
  HIF1α/VHL:2.0 µM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HIFs, HIF-1α/von Hippel-Lindau, HIF-PH, HIF/HIF Prolyl-Hydroxylase, Inhibitor, Hypoxia-inducible factors, inhibit, ZINC13466751, ZINC-13466751, ZINC 13466751

Compound Identifiers

PubChem CID

3120439