ZINC12409120

SKU: orb1688915

Description

ZINC12409120 (R-4584) is a selective ERK inhibitor with an IC50 of 5.0 µM. It functions by disrupting the FGF23:α-Klotho interaction, making it a useful research tool for studying ERK-dependent pathways in cancer and metabolic disorders in both cellular and animal models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1010888-06-8
• MW: 344.37
• Purity: 99.95% (May vary between batches)
• Formula: C₂₀H₁₆N₄O₂
• SMILES: C(=O)(C1=NC(C2=C3C(NC=C3)=CC=C2)=NO1)N4CC=5C(CC4)=CC=CC5
• Target: ERK
• Solubility: DMSO:50 mg/mL (145.19 mM)

Bioactivity

• Target IC50:
  ERK:5 μM
• In Vitro:
  ZINC12409120 (1 nM-0.1 mM; 5 h) inhibits ERK reporter activities mediated by FGF23 (1 μM), with an IC50 of 5 μM. ZINC12409120 (10 μM; 5 h) specifically inhibits ERK activity mediated by FGF23:α-Klotho instead of EGF-mediated ERK activation and exhibits no inhibitory effect on EGFR tyrosine kinase or EGF/EGFR interaction.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ZINC12409120, ZINC-12409120, ZINC 12409120, R4584, R-4584, R 4584, ERK

Compound Identifiers

PubChem CID

42581967