ZINC00784494

SKU: orb2278833

Description

ZINC00784494 is a selective LCN2 inhibitor that suppresses cancer cell proliferation by reducing AKT phosphorylation, inducing G0/G1 cell cycle arrest, and promoting apoptosis. It is a useful research tool for studying inflammatory breast cancer (IBC) in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 317328-17-9
• MW: 362.4
• Formula: C₂₀H₁₄N₂O₃S
• SMILES: O=C1OC=2C=CC=CC2C=C1C=3N=C(SC3)NC4=CC=CC(=C4)C(=O)C
• Target: Others
• Solubility: DMSO:80 mg/mL (220.75 mM)

Bioactivity

• In Vitro:
  Method: Cell viability assay was performed to evaluate the effect of ZINC00784494 on SUM149 cells. Cells were exposed to various concentrations of ZINC00784494 (0.01 to 100 µM) and incubated for 72 hours. Result: ZINC00784494 significantly reduced the viability of SUM149 cells at concentrations of 1 µM or lower.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ZINC 00784494

Compound Identifiers

PubChem CID

1075905