ZINC00640089

SKU: orb1744534

Description

ZINC00640089 is a selective LCN2 inhibitor that suppresses proliferation, viability, and AKT phosphorylation in SUM149 inflammatory breast cancer cells. This small molecule is a useful research tool for studying IBC mechanisms in vitro.

Research Area

Signal Transduction

Key Properties

• CAS Number: 667880-11-7
• MW: 370.32
• Purity: 99.89%
• Formula: C₂₀H₁₃F₃N₂O₂
• SMILES: C(C(NC1=C(C(F)(F)F)C=CC=C1)=O)N2C=3C4=C(C2=O)C=CC=C4C=CC3
• Target: Akt
• Solubility: DMSO:34.29 mg/mL (92.6 mM)

Bioactivity

• In Vitro:
  In SUM149 cells, ZINC00640089 (0.01-100 µM; 72 h) decreases cell proliferation and cell viability . Additionally, ZINC00640089 (1, 10 µM; 15 min, 1 h) reduces the levels of p-Akt in SUM149 cells .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LCN2

Compound Identifiers

PubChem CID

989246