Zigu-glucoside I

SKU: orb1222332

Description

Ziyuglycoside I has anti-inflammatory activity, could be used as an active ingredient for cosmetics.

Key Properties

• CAS Number: 35286-58-9
• MW: 766.97
• Purity: >98% (HPLC)
• Formula: C₄₁H₆₆O₁₃
• SMILES: C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]3[C@@]4(CC[C@@H](C3(C)C)O[C@H]3[C@@H]([C@H]([C@H](CO3)O)O)O)C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O
• Target: Others
• Solubility: In Vitro: Methanol : 125 mg/mL (162.98 )

Bioactivity

• In Vitro:
  Ziyuglycoside I (5-160 μM; 24 hours) reveals a marked anti-proliferation activity with an IC50 value of 13.96 μM in MDA-MB-231 cells. Ziyuglycoside I (5-20 μM; 24 hours) induces MDA-MB-231 cell apoptosis by increasing the percentage of apoptotic cells from 2.43% to 44.76% at 20 μM. Ziyuglycoside I (5-20 μM; 24 hours) induces the cleavage of caspas-8, caspase-9, and caspase-3, up-regulates the pro-apoptotic protein Bax, and down-regulates anti-apoptotic protein Bal-2, dose-dependently reduces the level of mito-cyto c expression. Cell Viability Assay Cell line: MDA-MB-231 cells. Concentration: 5 μM, 10 μM, 20 μM, 40 μM, 80 μM, and 160 μM. Incubation time: 24 hours. Result: Showed cytotoxicity on MDA-MB-231 cells. Cell Cycle Analysis Cell line: MDA-MB-231 cells. Concentration: 5 μM, 10 μM, and 20 μM. Incubation time: 24 hours. Result: Induced G2/M phase arrest and apoptosis on MDA-MB-231 Cells Western blot analysis. Cell line: MDA-MB-231 cells. Concentration: 5 μM, 10 μM, and 20 μM. Incubation time: 24 hours. Result: Induced apoptosis in MDA-MB-231 Cells through Intrinsic and Extrinsic Pathways.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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