ZG-2686

SKU: orb3173955

Description

ZG-2686 is a potent and selective agonist of HIF-2α with an EC50 of 0.25 µM, demonstrating selectivity for PHD2. It binds to a specific internal cavity of HIF-2α, forming hydrogen bonds through structural water molecules, which stabilizes the HIF-2α/β heterodimer and enhances its transcriptional activity. The compound acts synergistically with Vadadustat to upregulate HIF-2α-dependent EPO gene expression both in vitro and in vivo. ZG-2686 is applicable for renal anemia research.

Key Properties

• CAS Number: 1795110-22-3
• MW: 317.15
• Formula: C₁₃H₉BrN₄O
• SMILES: O=C(NC1=NNC=2N=CC=CC21)C3=CC=C(Br)C=C3
• Target: HIF/HIF Prolyl-Hydroxylase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HIF/HIF Prolyl-Hydroxylase