ZG-126

SKU: orb3134742

Description

ZG-126 is an agonist of the vitamin D receptor (VDR) and an inhibitor of histone deacetylase (HDAC) with an IC50 range of 0.63-67.6 μM. It demonstrates cytotoxicity in cancer cell lines MDA-MB-231 and 4T1. In mouse models, ZG-126 exhibits antitumor and antimetastatic effects against melanoma and triple-negative breast cancer (TNBC). Additionally, it shows anti-inflammatory activity by reducing macrophage infiltration and polarization to the immunosuppressive M2 subtype.

Key Properties

• CAS Number: 3049802-32-3
• MW: 513.67
• Formula: C₂₉H₄₃N₃O₅
• SMILES: O=C(NCCCCC(=O)NO)C1=CC=C(C=C1)C(C=2N=C(C(OCC(O)C(C)(C)C)=CC2)C)(CC)CC
• Target: Vitamin,HDAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Vitamin,HDAC