ZEN-3862

SKU: orb1708179

Description

ZEN-3862 (Willardiine) is a potent, dual-bromodomain BET inhibitor with IC50 values of 0.16 µM and 0.13 µM for BRD4(BD1) and BRD4(BD2), respectively. This small molecule serves as a versatile ligand for constructing PROTAC degraders to selectively deplete BRD4 protein levels in cellular and biochemical research.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1952264-33-3
• MW: 340.35
• Purity: 97.10%
• Formula: C₁₉H₁₇FN₂O₃
• SMILES: CC=1C(C2=CN(CC3=CC(F)=C(C=C3)C4CO4)C(=O)C=C2)=C(C)ON1
• Target: Epigenetic Reader Domain
• Solubility: DMSO:Soluble

Bioactivity

• Target IC50:
  BRD4 BD2:0.13 μM|BRD4 BD1:0.16 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EpigeneticReaderDomain, Epigenetic Reader Domain, BRD4BD1, BRD4-BD2, BRD4 BD2, BD1-BRD4, ZEN 3862, ZEN3862, ZEN-3862

Compound Identifiers

PubChem CID

121414853