ZD-4190

SKU: orb1301760

Description

ZD-4190 is a dual VEGFR2 and EGFR inhibitor used in cancer research. It has been studied in vitro for its anti-proliferative effects on tumor cells and in vivo in xenograft models to investigate angiogenesis and tumor growth inhibition.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 413599-62-9
• MW: 459.27
• Purity: 99.42% (May vary between batches)
• Formula: C₁₉H₁₆BrFN₆O₂
• SMILES: COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCn1ccnn1
• Target: EGFR,VEGFR
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (4.35 mM);DMSO:20.83 mg/mL (45.35 mM)

Bioactivity

• In Vivo:
  ZD4190 (100 mg/kg, p.o.) effectively delays MDA-MB-435 tumor growth in mice. In ZD4190-treated tumors, [18F-FPPRGD2] uptake significantly decreased by 26.74 ± 8.12% (p<0.05) on day 1 and by 41.19 ± 6.63% (p<0.01) on day 3, returning to baseline by day 7. Tumor uptake of [18F-FLT] also decreased on days 1 and 3 after initiating ZD4190 treatment. However, ZD4190 did not significantly alter [18F-FDG] uptake compared to the control group.
• In Vitro:
  ZD4190 can prevent outgrowth of malignant cells when the tumour burden is below a critical threshold.
• Animal Research:
  ZD4190 was administered by gavage suspended in 1% polysorbate 80 at 50 mg/kg 24 h after tumour cell implantation for a maximum of 22 days. Control rodents were gavaged with the vehicle only and a third group was untreated. In preliminary experiments, rodents were killed on alternate days so that the effect of ZD4190 on tumour outgrowth could be assessed and subsequently the treatment response was evaluated at day 9 or 22. At least five rodents were included in each treatment group.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, HER1, Epidermal growth factor receptor, EGFR, ErbB-1, inhibit, VEGFR2, VEGFR, Vascular endothelial growth factor receptor, ZD4190, ZD-4190, ZD 4190

Compound Identifiers

PubChem CID

5329032