ZCL278

SKU: orb1307317

Description

ZCL278

Research Area

Cell Biology, Infectious Disease & Virology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 587841-73-4
• MW: 584.894
• Purity: 99.72% (May vary between batches)
• Formula: C₂₁H₁₉BrClN₅O₄S₂
• SMILES: CC1=CC(C)=NC(NS(=O)(=O)C2=CC=C(NC(=S)NC(=O)COC3=C(Cl)C=C(Br)C=C3)C=C2)=N1
• Target: Influenza Virus,Anti-infection,Ras,CDK
• Solubility: DMSO:40 mg/mL (68.39 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.42 mM)

Bioactivity

• Target IC50:
  GTPase CDC42:11.4 μM(Kd)
• In Vivo:
  ZCL278 reduces the JUNV RNA load in the spleen by over 33-fold, rendering JUNV RNA undetectable in 5 of 8 mice. These results mirror those observed in Gabapentin-treated mice, demonstrating ZCL278's ability to abrogate JUNV replication .
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• Cell Research:
  ZCL278 is prepared in DMSO and stored, and then diluted with appropriate medium before use. To determine cell viability, PC-3 cells are incubated for 24 h with or without the Cdc42 activator, ZCL278, or NSC23766. By using the trypan blue dye exclusion method, the numbers of live and dead cells are obtained with a Countess Automated Cell Counter. P values are assigned in each experiment, and any null hypothesis with probability level <95% is rejected.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

organization, metastatic, inhibit, Golgi, Inhibitor, motility, cellular, Cdc42-ZCL278, Cdc42 GTPase, Cdc42, cancer, actin-based, Ras, prostate, ZCL 278, ZCL278, ZCL-278

Compound Identifiers

PubChem CID

1791111