Zavondemstat

SKU: orb1739359

Description

Zavondemstat (QC8222 free base) is a potent and selective KDM4 inhibitor used in cancer research. It has demonstrated antitumor activity in both in vitro and in vivo studies, making it a valuable tool for investigating therapeutic strategies against triple-negative breast cancer (TNBC) and other malignancies.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1851412-93-5
• MW: 431.53
• Purity: 99.78% (May vary between batches)
• Formula: C₂₆H₂₉N₃O₃
• SMILES: C(NC=1C(C(O)=O)=CC=NC1)[C@H]2C=3C(=CC(N(C)C4=CC=C(C(C)C)C=C4)=CC3)OCC2
• Target: Histone Demethylase
• Solubility: DMSO:7.25 mg/mL (16.8 mM)

Bioactivity

• Target IC50:
  KDM4 isoforms A-D:80 nM|KDM5 family members:140-400 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TACH 101, TACH 101 free base, TACH101, TACH-101, Zavondemstat, QC8222, QC-8222, QC8222 free base, QC 8222, KDM4, Histone Demethylase, HistoneDemethylase

Compound Identifiers

PubChem CID

118597685