ZAK-IN-1

SKU: orb3135151

Description

ZAK-IN-1 is an orally active and selective inhibitor of the leucine zipper and sterile-alpha motif kinase ZAK, with an IC50 of 4 nM and a KD of 8 nM. It demonstrates exceptional selectivity against 403 types of wild-type kinases. ZAK-IN-1 effectively blocks the p38/GATA-4 and JNK/c-Jun signaling pathways, significantly suppressing cardiac hypertrophy. This compound is applicable in the study of hypertrophic cardiomyopathy (HCM).

Research Area

Signal Transduction

Key Properties

• CAS Number: 2362525-64-0
• MW: 559.55
• Formula: C₂₇H₁₉F₂N₇O₃S
• SMILES: O=S(=O)(NC1=CC=C(F)C(=C1F)N2N=NC(=C2)C=3C=NC=4NN=C(OC)C4C3)C5=CC=CC(=C5)C=6C=CC=CC6
• Target: MAPK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MAPK