Z21115

SKU: orb2663581

Description

Z21115 is a potent and orally active PDE4 inhibitor, specifically targeting PDE4D7 (IC50 = 10.5 nM). It reduces pro-inflammatory markers like IL-6 and TNF-α in vitro and shows efficacy in a DSS-induced colitis mouse model, demonstrating anti-inflammatory activity with a high tolerability profile.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2958668-54-5
• MW: 390.38
• Formula: C₂₀H₂₀F₂N₂O₄
• SMILES: FC(F)OC1=CC=C(C=2C=C(OC)C(OC)=C(OC)C2)C3=CN(N=C13)C4CC4
• Target: PDE

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172638504