Z-YVAD-FMK

SKU: orb1296602

Description

AA-Z-YVAD-FMK is an irreversible caspase-1 inhibitor used in research to study inflammasome pathways. Its anti-inflammatory and anti-tumor properties make it a valuable tool for in vitro and in vivo investigations of diseases like sepsis and cancer.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 210344-97-1
• MW: 630.66
• Purity: 98.00%
• Formula: C₃₁H₃₉FN₄O₉
• SMILES: COC(=O)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1)C(C)C)C(=O)CF
• Target: Caspase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (7.93 mM);DMSO:250 mg/mL (396.41 mM)

Bioactivity

• In Vitro:
  Z-YVAD-FMK (100 μM; 24 hours) significantly mitigated butyrate-induced growth inhibition in Caco-2 cells.

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Z YVAD FMK, ZYVADFMK, Z-YVAD-FMK, Caspase, Caspase 1, Caspase 4, caspase-1, Anti-inflammatory, anti-tumor, inhibit, Inhibitor

Compound Identifiers

PubChem CID

644196