Z-VAD-FMK

• Catalog Number: orb1147018
• Category: Proteins
• Description: Pan-caspase inhibitor; Peptides.
• CAS Number: 187389-52-2
• Form/Appearance: White lyophilised solid
• Purity: > 98% by TLC
• MW: 467.49 Da
• Formula: C₂₂H₃₀FN₃O₇
• Structure: Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
• Solubility (25°C): Soluble to 10 mg/mL in DMSO
• Protein Sequence: Z-VAD-FMK
• Storage: Store dry, dark and frozen
• Alternative names: 187389-52-2PI250, Z-VAD-FMK, Z-Val-Ala-Asp(OMe)-FM
• Background: Z-VAD-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable, irreversible pan-caspase inhibitor. Z-VAD-FMK inhibits caspase processing and apoptosis induction in tumour cells in vitro with an IC50 of 0.0015 - 5.8 mM). Z-VAD-FMK is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability. Z-VAD-FMK is active in vivo and can inhibit apoptosis in numerous settings.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.