(Z)-PUGNAc

SKU: orb1691820

Description

(Z)-PUGNAc is a cell-permeable, potent and selective inhibitor of O-GlcNAcase (OGA), the enzyme that removes O-GlcNAc modifications from proteins. Its application in both in vitro and in vivo studies effectively elevates global O-GlcNAcylation levels, making it a valuable tool for researching nutrient sensing, cellular stress, and signaling pathways in models of diabetes, neurodegeneration, and cancer.

Key Properties

• CAS Number: 132489-69-1
• MW: 353.33
• Purity: 98.72%
• Formula: C₁₅H₁₉N₃O₇
• SMILES: CC(=O)NC1C(O)C(O)C(CO)OC1=NOC(=O)Nc1ccccc1
• Target: Others
• Solubility: DMSO:127.5 mg/mL (360.85 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.83 mM)

Bioactivity

• In Vitro:
  In HeLa and HEK cell systems, (Z)-PugNAc amplifies the incorporation of O-GlcNAc onto proteins.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(Z)PUGNAc, (Z) PUGNAc, O-GlcNAcase, PUGNAc

Compound Identifiers

PubChem CID

4343649