YYSW001

SKU: orb3211361

Description

YYSW001 is an orally active and selective JAK1 inhibitor with an IC50 of 6 nM and a Kd of 32.32 μM. It effectively blocks JAK1-dependent STAT6 phosphorylation and IL-6-induced STAT3 phosphorylation. YYSW001 reduces pro-inflammatory cytokine levels, alleviates paw swelling, decreases clinical arthritis scores, mitigates joint damage, and reduces bone loss, making it a valuable compound for rheumatoid arthritis research.

Key Properties

• CAS Number: 2763672-36-0
• MW: 417.38
• Formula: C₁₈H₂₀F₅N₅O
• SMILES: [C@H](C)(O)C=1N(C2=C3C(NC=C2N1)=NC=C3)[C@@H]4CN(CCC(C(F)(F)F)(F)F)CC4
• Target: STAT,JAK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

STAT,JAK