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YX-02-030

SKU: orb3132697

Description

YX-02-030M is a PROTACMDM2 degrader. It inhibits the binding of MDM2 to p53 and VHL to HIF1α, with IC50 values of 63 nM and 1.35 μM, respectively. YX-02-030M binds to MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, effectively killing p53 mutant or deficient triple-negative breast cancer (TNBC) cells.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number3049076-98-1
MW1267.41
FormulaC66H85Cl2N9O10S
SMILESC[C@@]1(N(C(=O)N2CCN(CC(NCCOCCOCCOCC(N[C@H](C(=O)N3[C@H](C(NCC4=CC=C(C=C4)C5=C(C)N=CS5)=O)C[C@@H](O)C3)[C@@](C)(C)C)=O)=O)CC2)C(=N[C@@]1(C)C6=CC=C(Cl)C=C6)C7=C(OCC)C=C(C(C)(C)C)C=C7)C8=CC=C(Cl)C=C8
TargetMDM-2/p53,PROTACs

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

YX-02-030 (orb3132697)

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