YW1128

SKU: orb1694522

Description

YW1128 is a potent small molecule inhibitor of the Wnt/β-catenin pathway, exhibiting an IC50 of 4.1 nM. It reduces β-catenin and elevates Axin1 protein levels in vitro. In vivo, it ameliorates diet-induced metabolic dysfunction, improving glucose tolerance and reducing hepatic steatosis in mouse models.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2131223-64-6
• MW: 343.38
• Formula: C₂₀H₁₇N₅O
• SMILES: CC=1N(N=NC1C(NC2=NC3=C(C=C2)C=CC=C3)=O)C4=C(C)C=CC=C4
• Target: Wnt/beta-catenin,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

137375558