YU241279

SKU: orb3211193

Description

YU241279 is an orally active inhibitor of CXCR5. It blocks the CXCL13-mediated Gαq-dependent calcium influx and the Gαi2-dependent cAMP reduction in cells expressing CXCR5. Additionally, YU241279 inhibits the proliferation of lymphoma cells expressing CXCR5 and reduces tumor burden in peripheral blood and bone marrow of mice with implanted lymphoma tissues. It is well-tolerated in mice, maintains stable plasma concentration, and shows no metabolic changes upon oral administration. YU241279 is applicable for research in angioimmunoblastic T-cell lymphoma and Burkitt B-cell lymphoma.

Key Properties

• CAS Number: 1092445-63-0
• MW: 351.44
• Formula: C₂₂H₂₅NO₃
• SMILES: O=C(O)C1(NC(=O)C2=CC=CC(=C2CC(C)C)C)CC=3C=CC=CC3C1
• Target: CXCR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CXCR