YTX-465

SKU: orb1297918

Description

YTX-465 is a dual inhibitor of stearoyl-CoA desaturase (SCD1) and the yeast enzyme Ole1, with respective IC50 values of 39 nM and 30.4 µM. This small molecule is a valuable research tool for investigating lipid metabolism in both cellular (in vitro) and organismal (in vivo) models, particularly in studies related to metabolic disorders and cancer.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2225824-53-1
• MW: 458.51
• Purity: 99.41% (May vary between batches)
• Formula: C₂₅H₂₆N₆O₃
• SMILES: Cc1nn(C)c2cc(ccc12)-c1noc(n1)C1CCN(CC1)C(=O)CNC(=O)c1ccccc1
• Target: Stearoyl-CoA Desaturase (SCD)
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.36 mM);DMSO:50 mg/mL (109.05 mM)

Bioactivity

• Target IC50:
  SCD:30.4 μM|Ole1:39 nM
• In Vitro:
  YTX-465 rescued growth to a similar magnitude but was >100-fold more potent than YTX-528(EC50 = 0.013 μM). Kinetic growth studies demonstrated that the most effective concentration of YTX-465 (0.050 μM) restored growth rates to that of approximately 40% of the wild-type strain treated with the same concentration of YTX-465. In wild-type yeast, YTX-465 strongly reduced fatty desaturation in a concentration-dependent manner, with a 50% reduction in desaturation at 0.03 μM YTX-465.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SCD, synucleinopathies, StearoylCoA Desaturase (SCD), Stearoyl-CoA Desaturase (SCD), StearoylCoADesaturase, Stearoyl-CoA Desaturase, StearoylCoADesaturase(SCD), YTX 465, YTX465, YTX-465, α-synuclein, inhibit, Ole1, Parkinson's disease, fatty desaturation, Inhibitor

Compound Identifiers

PubChem CID

134477586