YS-49

SKU: orb1308928

Description

YS-49 is a small molecule activator of the PI3K/Akt signaling pathway, which acts downstream of RhoA. It is utilized in biochemical and cell-based research to study this pathway's role in processes such as cell survival, proliferation, and metabolism in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 132836-42-1
• MW: 386.28
• Purity: 99.65%
• Formula: C₂₀H₂₀BrNO₂
• SMILES: Br.Oc1cc2CCNC(Cc3cccc4ccccc34)c2cc1O
• Target: Adrenergic Receptor,RAAS,Akt,PI3K
• Solubility: DMSO:250 mg/mL (647.2 mM);H2O:10 mg/mL (25.89 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.36 mM)

Bioactivity

• In Vivo:
  In male Sprague Dawley rats,YS-49 (5mg/kg; intraperitoneal injection; 8 hours) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM.
• In Vitro:
  In RAVSMC and RAW 264.7 cells, YS-49 (1-100 μM; 18 hours; ) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC50 values of 22 μM and 30 μM, respectively.At the transcriptional level, YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Angiotensin Receptor, Adrenergic Receptor, AdrenergicReceptor, Akt, Beta Receptor, Inhibitor, inhibit, YS 49, YS49, YS-49, Protein kinase B, Phosphoinositide 3-kinase, PKB, PI3K, β-adrenoceptor

Compound Identifiers

PubChem CID

10249534