YN11

SKU: orb3211128

Description

YN11 is a STAT3 inhibitor with a dissociation constant (Kd) of 11.9 μM. It directly binds to the SH2 domain of STAT3, suppressing its phosphorylation and reducing the expression of downstream target proteins. YN11 induces cell cycle arrest, promotes apoptosis, and inhibits invasion and migration in prostate cancer cells. It also suppresses tumor growth in xenograft mouse models of prostate cancer without causing significant weight loss or prominent histopathological changes in major organs. YN11 is valuable for research related to prostate cancer.

Key Properties

• CAS Number: 3118507-43-7
• MW: 510.52
• Formula: C₂₅H₂₂N₂O₈S
• SMILES: O=C1C=2OC(=CC2C(=O)C=3C=CC=CC13)C(=O)N4CCN(CC4)S(=O)(=O)C5=CC=C(OC)C(OC)=C5
• Target: Apoptosis,STAT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,STAT