YLIU-4-105-1

SKU: orb2695375

Description

YLIU-4-105-1 is a potent and selective type II JAK2 inhibitor. It demonstrates robust in vivo efficacy by dose-dependently reducing splenomegaly and reticulocytosis, and it directly suppresses JAK2 signaling via inhibition of pSTAT5. This compound is a valuable research tool for investigating JAK2-driven pathologies such as myeloproliferative neoplasms in both cellular and animal models.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2417685-83-5
• MW: 605.65
• Formula: C₃₂H₃₄F₃N₇O₂
• SMILES: O=C(NC=1C=C(C=C(C1)C(F)(F)F)CN2CCN(CC)CC2)C=3C=CC(=C(C3)C4=NN5C=C(N=C5C=C4)NC(=O)C6CC6)C
• Target: JAK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

153583901