YL1004

SKU: orb3211120

Description

YL1004 is a potent, selective, and orally effective non-covalent inhibitor that targets the SARS-CoV-2 papain-like protease (PLpro). It has an IC50 of 17.5 nM and a Ki of 2.3 nM against PLpro, with an in vitro anti-SARS-CoV-2 EC50 ranging from 0.08 μM to 1.37 μM. YL1004 inhibits the proteolytic activity of PLpro and blocks its deubiquitination and de-ISGylation activities, thereby restoring the host's innate antiviral immune signaling pathways. It effectively inhibits the replication of SARS-CoV-2 wild type, Delta variant, Omicron variant, and nirmatrelvir-resistant strains. YL1004 is applicable for research on COVID-19 (SARS-CoV-2 infection).

Key Properties

• Target: SARS-CoV,Virus Protease

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

SARS-CoV,Virus Protease