YKL-06-062

SKU: orb1706458

Description

YKL-06-062 is a potent and selective second-generation inhibitor of salt-inducible kinases (SIK1, SIK2, and SIK3), exhibiting low nanomolar IC50 values. This compound is a valuable chemical probe for investigating SIK signaling in immunological, metabolic, and cancer research, both in cellular and animal models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2172617-16-0
• MW: 525.69
• Purity: 99.95% (May vary between batches)
• Formula: C₃₁H₃₉N₇O
• SMILES: CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N(C4CCCCC4)c3n2)c2c(C)cccc2C)cc1
• Target: SIK
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  SIK1:2.12 nM|SIK2:1.40 nM|SIK3:2.86 nM
• In Vitro:
  In a dose-dependent manner, YKL 06-062 (0.0004-16 μM; 3 h) enhances MITF mRNA expression.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Salt-inducible Kinase (SIK), YKL06062, YKL-06-062, YKL 06 062

Compound Identifiers

PubChem CID

139600310