YJ9069

SKU: orb2695287

Description

YJ9069 is a potent and selective CDK12/CDK13 PROTAC degrader (IC50 = 22.22 nM in VCaP cells). It induces transcription-dependent DNA damage and cell cycle arrest, effectively inhibiting prostate cancer cell proliferation in vitro and suppressing tumor growth in vivo, making it a valuable tool for oncology and targeted protein degradation research.

Research Area

Cell Biology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• MW: 850.92
• Formula: C₄₆H₄₆N₁₀O₇
• SMILES: FC=1C=2C3=C(N4[C@](COC3=NC1C=5C(=C(Cl)C=C6C5C=NN6)C7CC7)(COCCC4)[H])N=C(OC[C@@]89N(CC(=C)C8)CCC9)N2
• Target: DNA/RNA Synthesis|||PROTACs|||CDK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172194214