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YF135

SKU: orb1983026

Description

YF135, a reversible-covalent KRAS G12C PROTAC, effectively induces the degradation of KRAS G12C and reduces phospho-ERK levels via the E3 ligase VHL-mediated proteasome pathway. Designed by integrating the KRAS G12C inhibitor 48 (compound 6d) as the ligand, YF135 utilizes the MRTX849 linkage VHL ligand scaffold.

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Key Properties

CAS Number2913177-53-2
MW1179.86
FormulaC63H75ClN12O7S
SMILESCc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCCN2CCC[C@H]2COc2nc3CN(CCc3c(n2)N2CCN([C@@H](CC#N)C2)C(=O)C(=C\C2CC2)\C#N)c2cccc3cccc(Cl)c23)C(C)(C)C)cc1
TargetPERK,Ras,PROTACs,Kras,Others

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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Protocol Information

YF135 (orb1983026)

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