YF135

SKU: orb1983026

Description

YF135 is a reversible-covalent KRAS G12C PROTAC that degrades the oncogenic protein via VHL E3 ligase recruitment and proteasomal destruction, leading to reduced phospho-ERK signaling. This bifunctional molecule, derived from MRTX849 and a VHL ligand, is a valuable chemical tool for investigating KRAS-driven cancers in both cellular and animal models.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2913177-53-2
• MW: 1179.86
• Formula: C₆₃H₇₅ClN₁₂O₇S
• SMILES: Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCCN2CCC[C@H]2COc2nc3CN(CCc3c(n2)N2CCN([C@@H](CC#N)C2)C(=O)C(=C\C2CC2)\C#N)c2cccc3cccc(Cl)c23)C(C)(C)C)cc1
• Target: ERK,Kras,Ras,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

163322223