YCH3292

SKU: orb3174991

Description

YCH3292, a derivative of YCH189, is a potent, selective, and orally active PARP1/2 inhibitor with IC50 values of less than 0.001 nM. YCH3292 enhances the stability of PARP-DNA complexes and exhibits strong antiproliferative activity. It induces DNA double-strand breaks, increases protein levels of γH2AX, P-RPA32, and P-Chk1, and causes tumor cells to undergo S phase or G2/M phase arrest and apoptosis (apoptosis). In the MC38 xenograft model, YCH3292 effectively suppresses tumor growth.

Key Properties

• CAS Number: 3049753-10-5
• MW: 510.53
• Formula: C₂₈H₂₃FN₆O₃
• SMILES: O=C1NN=C(C=2C=CC=CC12)CC3=CC=C(F)C(=C3)C(=O)N4CC5=NN=C(C=6OC(=CC6)C7CC7)N5CC4
• Target: PARP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PARP