YB-3–17

SKU: orb2945976

Description

YB-3-17 is a potent bifunctional molecule acting as an mTOR inhibitor (IC50=0.22 nM) and a GSPT1 degrader (DC50=5 nM). It demonstrates nanomolar antiproliferative activity in glioblastoma cell lines and has shown antitumor efficacy in mouse models, supporting its use in oncology and targeted protein degradation research.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2940242-88-4
• MW: 745.786
• Formula: C₃₈H₃₉N₁₁O₆
• SMILES: O=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2=O)NCC4CCC(C(=O)N5CCC(N6N=C(C=7C=CC=8OC(=NC8C7)N)C=9C(=NC=NC96)N)CC5)CC4)CC1
• Target: PROTACs,mTOR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172677415