YB-0158 ammonium

SKU: orb2567329

Description

YB-0158 ammonium is a reverse-rotation peptidomimetic that inhibits the Wnt pathway and exhibits anticancer properties. It functions by disrupting the Sam68-Src interaction, leading to apoptosis in colorectal cancer cells in vitro, making it a useful tool for oncology and signal transduction research.

Research Area

Cell Biology

Key Properties

• MW: 693.69
• Purity: >99.99% (May vary between batches)
• Formula: C₃₂H₄₀N₉O₇P
• SMILES: [NH4+].[NH4+].[H][C@]12CN(Cc3cccc4cn[nH]c34)C(=O)[C@H](Cc3ccc(OP([O-])([O-])=O)cc3)N1C(=O)CN(CC=C)N2C(=O)NCc1ccccc1
• Target: Apoptosis

Bioactivity

• Target IC50:
  FGFR1:8 nM|c-Kit:2 nM|FLT3:1 nM|PDGFRβ:27 nM|PDGFRα:210 nM|FGFR3:9 nM|VEGFR2:13 nM|VEGFR3/FLT4:8 nM
• In Vivo:
  b>METHODS: Primary mouse recipients were treated with YB-0158 ammonium (100 mg/kg), and the presence or absence of secondary tumors was determined by live fluorescence tumor imaging. RESULTS: No significant differences in primary tumor size were observed in YB-0158 ammonium-treated mice compared to saline controls.
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• In Vitro:
  b>METHODS: YB-0158 ammonium (0.2 μM and 0.5 μM, 48 hours) treated HT29 cells RESULTS: Lower doses of YB-0158 ammonium were sufficient to significantly reduce the proliferation of human CRC cells. When used at 0.5 μM, YB-0158 ammonium also significantly increased the apoptosis of CRC cells, as measured by the activated Caspase-3/7 detection assay. represent.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

YB 0158 ammonium, YB0158 ammonium, YB0158ammonium, Wnt pathway inhibitor 2 ammonium, Apoptosis

Compound Identifiers

PubChem CID

172011136