YAP/TAZ-TEAD-IN-2

SKU: orb2802204

Description

YAP/TAZ-TEAD-IN-2 (Compound 51) is a potent, nanomolar inhibitor of the YAP/TAZ-TEAD protein-protein interaction, blocking downstream oncogenic transcription. It effectively reduces target gene expression (e.g., Cyr61, CTGF) and inhibits breast cancer cell proliferation in vitro, making it a valuable chemical probe for Hippo pathway and cancer research.

Research Area

Cancer Biology, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• MW: 356.44
• Formula: C₁₉H₂₀N₂O₃S
• SMILES: C=CS(NCCN(C=C1)C(C1=C2)=CC=C2OCC3=CC=CC=C3)(=O)=O
• Target: Survivin,YAP,PKC,TAM Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176419262