Yadanzigan

SKU: orb2944186

Description

Yadanzigan (YDZG) is a natural NLRP3 inhibitor derived from Brucea javanica. It suppresses the NF-κB pathway and mitochondrial ROS while upregulating anti-inflammatory TRIM31, demonstrating protective effects in models of LPS-induced acute lung injury in both cellular and animal studies.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 76588-87-9
• MW: 574.57
• Purity: 99.98% (May vary between batches)
• Formula: C₂₆H₃₈O₁₄
• SMILES: O=C1OC2CC3C(=CC(OC4OC(CO)C(O)C(O)C4O)C(O)C3(C)C5C(O)C(O)C6(OCC25C6(O)C1O)C)C
• Target: NF-κB,NOD,NOD-like Receptor (NLR),ROS

Bioactivity

• In Vivo:
  In LPS-induced acute lung injury (ALI) mouse models, intravenous administration of Yadanzigan (5 or 10 mg/kg) significantly reduced NLRP3 and caspase-1 expression in lung tissues, alleviated histopathological damage, lowered leukocyte infiltration and inflammatory cytokines (IL-1β, TNF-α, IL-6), and improved survival.
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• In Vitro:
  Yadanzigan (20–80 μM; 24 h) significantly inhibited LPS (1 μg/mL) + ATP (5 mM)–induced NLRP3 inflammasome activation in RAW264.7, J774A.1, and THP-1 macrophages, reducing caspase-1 and IL-1β expression/secretion, enhancing TRIM31 expression, and suppressing mitochondrial ROS production.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

YDZG

Compound Identifiers

PubChem CID

162953791