Y-320

SKU: orb1307339

Description

Y-320 is a novel small molecule immunomodulator belonging to the phenylpyrazoleanilide class. It is utilized in research to investigate immune signaling pathways and has demonstrated activity in both cellular assays and animal models of autoimmune disease.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 288250-47-5
• MW: 505.01
• Purity: 99.64% (May vary between batches)
• Formula: C₂₇H₂₉ClN₆O₂
• SMILES: Cc1c(cnn1-c1ccc(Cl)cc1)C(=O)Nc1ccc(N2CCC(CC2)N2CCOCC2)c(c1)C#N
• Target: Interleukin,IL Receptor,Lipase,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (0.99 mM);DMSO:9 mg/mL (17.82 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  IL-17 production:20-60 nM
• In Vivo:
  Y-320 (administered orally at doses of 0.3-3 mg/kg) enhances the improvement of collagen-induced arthritis (CIA) in mice, concurrently reducing the expression levels of IL-17 mRNA within arthritic joints. Additionally, it has demonstrated therapeutic efficacy for CIA in crab-eating macaques.
• In Vitro:
  Y-320 can inhibit the production of IFN-γ and TNF-α in mouse CD4 T cells stimulated by IL-15, CXCL12, and anti-CD3 monoclonal antibody.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

G418, ILReceptor, IL Receptor, IL-17 production, Inhibitor, Interleukin Related, Interleukin, immunomodulator, inhibit, anticancer, Apoptosis, ATGL, rheumatoid arthritis, Y320, Y-320, protein synthesis, Y 320, phenylpyrazoleanilide

Compound Identifiers

PubChem CID

22227931