Y-29794 Tosylate

SKU: orb1304121

Description

Y-29794 Tosylate is a potent, specific, and orally bioavailable inhibitor of prolyl endopeptidase (PPCE). This small molecule research tool is used in vitro and in vivo to investigate the role of PPCE in neurological processes and cognitive function.

Research Area

Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 143984-17-2
• MW: 590.86
• Purity: 99.86% (May vary between batches)
• Formula: C₃₀H₄₂N₂O₄S₃
• SMILES: CC(C1=CC=C(C(C2=CC=CS2)=O)C(SCCCCCCCCN(C)C)=N1)C.CC3=CC=C(S(=O)(O)=O)C=C3
• Target: Prolyl Endopeptidase (PREP)
• Solubility: DMSO:50 mg/mL (84.62 mM)

Bioactivity

• Target IC50:
  PREP:3 nM
• In Vivo:
  Y-29794 Tosylate selectively and competitively inhibited rat brain PPCE in a reversible manner. Y-29794 Tosylate was found to potentiate the effect of TRH on the release of ACh in the rat hippocampus.
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• In Vitro:
  Y-29794 Tosylate could penetrate into brain to exhibit dose-dependent and long-lasting inhibition.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PREP, Y29794, Y-29794, Y29794 Tosylate, Y29794 tosylate, Y-29794 Tosylate, Y 29794 Tosylate, Y 29794, prolyl endopeptidase, Prolyl Endopeptidase (PREP), Prolyl Endopeptidase, ProlylEndopeptidase, ProlylEndopeptidase(PREP)

Compound Identifiers

PubChem CID

9851449