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XZ739

SKU: orb1690971

Description

XZ739 is a potent, Cereblon-dependent PROTAC that selectively degrades BCL-XL, inducing caspase-mediated apoptosis. It demonstrates high potency with a DC50 of 2.5 nM in MOLT-4 cells and is a valuable chemical probe for studying apoptosis and BCL-2 family biology in cancer research.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2365172-19-4
MW1349.99
FormulaC65H76ClF3N8O12S3
SMILESCN(CCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)CC[C@H](CSc1ccccc1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(CC2=C(CCC(C)(C)C2)c2ccc(Cl)cc2)CC1 |t:81|
TargetApoptosis,Bcl-2 Family,PROTACs

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information