Xyloidone

SKU: orb1306799

Description

Xyloidone (NSC-106453) is a broad-spectrum antifungal agent that potently inhibits mycelial growth of pathogenic fungi including Botrytis cinerea and Colletotrichum species. It is a valuable tool for in vitro phytopathology research, facilitating studies on fungal inhibition mechanisms and plant disease control.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 15297-92-4
• MW: 240.25
• Purity: 99.58%
• Formula: C₁₅H₁₂O₃
• SMILES: O=C1C2=C(C(=O)C=3C1=CC=CC3)C=CC(C)(C)O2
• Target: Antifungal
• Solubility: DMSO:Soluble

Bioactivity

• In Vivo:
  Xyloidone inhibits vessel regeneration, interferes with vessel anastomosis, and limits plexus formation in zebrafish. Xyloidone induces vascular pruning and growth delay in orthotopic mammary tumors in mice. Xyloidone targets cell adhesion by promoting ubiquitination of the Rho-GTPase Rac1, which is frequently up-regulated in many different cancers.
• In Vitro:
  Xyloidone controlls the development of rice blast, tomato late blight, wheat leaf rust, barley powdery mildew and red pepper anthracnose (Colletotrichum coccodes (Wallr) S Hughes). Xyloidone is particularly effective in suppressing red pepper anthracnose by 95% at a concentration of 125 mg/L.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC629748, NSC-629748, NSC106453, NSC-106453, NSC 629748, NSC 106453, Dehydrolapachone, Dehydro-a-lapachone, Dehydro-alpha-lapachone, Dehydro-α-lapachone, Antifungal, Xyloidone

Compound Identifiers

PubChem CID

72734