XY221

SKU: orb2945165

Description

Compound 16o (XY221) is a potent and highly selective BRD4 BD2 inhibitor (IC50 = 5.8 nM), showing >600-fold selectivity over BRD4 BD1. It induces apoptosis in MV4-11 leukemia cells and exhibits anti-cancer activity in cellular assays, supporting its use in oncology and epigenetics research.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• MW: 559.628
• Formula: C₃₂H₃₄FN₃O₅
• SMILES: CCC1=NC(=C(N1)COC)C2=CC3=C(O2)C(=CN(C3=O)C)C4=C(C=CC(=C4)C(C)(C)O)OC5=C(C=C(C=C5C)F)C
• Target: AMPK,Bcl-2 Family,c-Myc,Apoptosis,PAK,Epigenetic Reader Domain

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172432157