XU1

SKU: orb1698958

Description

XU1 is a small molecule inhibitor targeting Aurora kinases, useful for studying kinase signaling pathways in cancer research. It has been employed in both in vitro enzymatic assays and in vivo models to investigate its effects on cell cycle progression and tumor growth.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 53439-81-9
• MW: 196.2
• Purity: 97.81% (May vary between batches)
• Formula: C₁₂H₈N₂O
• SMILES: O=C1C2=C(C=3C(N1)=NC=CC3)C=CC=C2
• Target: Adenosine Receptor,PARP,Aurora Kinase
• Solubility: DMSO:3.85 mg/mL (19.62 mM)

Bioactivity

• Target IC50:
  A2A receptor (human):4.8 μM (Ki)|PARP1:0.311 μM|A1AR (human):4.6 μM (Ki)|Aurora A:5.5 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aurora A, Aurora Kinase, AuroraKinase, Benzo[c][1,8]naphthyridin-6(5h)-One, XU1, XU-1, XU 1

Compound Identifiers

PubChem CID

12342815