XSJ151

SKU: orb3174715

Description

XSJ151 is a topoisomerase I inhibitor that stabilizes the DNA-topoisomerase I covalent complex, inducing DNA double-strand breaks. The DNA damage caused by XSJ151 activates the p53-p21 signaling pathway, specifically regulating the expression of cyclins, resulting in G2/M phase cell cycle arrest. Additionally, it disrupts the dynamic equilibrium of Bcl-2 family proteins, thereby triggering apoptosis in gastric cancer cells. XSJ151 is applicable for research in gastric cancer.

Key Properties

• CAS Number: 1685279-23-5
• MW: 737.74
• Formula: C₃₇H₃₁N₅O₁₀S
• SMILES: O(C(CN=C(CC1=CC=C(OC)C=C1)NS(=O)(=O)C2=CC=C(N(=O)=O)C=C2)=O)[C@@]3(CC)C4=C(C(=O)N5C(=C4)C=6C(C5)=CC=7C(N6)=CC=CC7)COC3=O
• Target: MDM-2/p53,Bcl-2 Family,DNA/RNA Synthesis,Topoisomerase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MDM-2/p53,Bcl-2 Family,DNA/RNA Synthesis,Topoisomerase