XR-11576 HCl

SKU: orb1745246

Description

XR-11576 HCl is a small molecule research compound that functions as a dual inhibitor of topoisomerase I and II, exhibiting oral bioavailability. Its antitumor properties have been investigated in both in vitro cytotoxicity assays and in vivo xenograft models, supporting its use in oncology and cancer mechanism studies.

Research Area

Molecular Biology

Key Properties

• MW: 424.92
• Purity: 98.52% (May vary between batches)
• Formula: C₂₃H₂₅ClN₄O₂
• SMILES: COC1=CC=CC2=C3C(N=C4C(C(C(N[C@H](C)CN(C)C)=O)=CC=C4)=N3)=CC=C12.Cl
• Target: Topoisomerase
• Solubility: DMSO:45 mg/mL (105.9 mM)

Bioactivity

• Target IC50:
  COR-L23 cells:0.0101 µM|MRP:0.0121 µM
• In Vitro:
  XR-11576 has an inhibitory effect (IC50=0.0121 µ M) on multidrug-resistant human non-small cell lung cancer cell line COR-L23 (COR-L23/R) overexpressing multidrug-resistant protein (MRP).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

XR-11576 HCl, XR-11576 HCl(346689-77-8 Free base), topoisomerase I, topoisomerase II

Compound Identifiers

PubChem CID

169553385