XL388

SKU: orb1301136

Description

XL388 is a potent and selective ATP-competitive mTOR inhibitor with an IC50 of 9.9 nM, demonstrating >1000-fold selectivity over related PI3K kinases. This small molecule is a valuable research tool for studying mTOR signaling in cancer, aging, and metabolic diseases, applicable in both cellular and animal models.

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1251156-08-7
• MW: 455.5
• Purity: 99.39%
• Formula: C₂₃H₂₂FN₃O₄S
• SMILES: Cc1c(F)c(ccc1C(=O)N1CCOc2ccc(cc2C1)-c1ccc(N)nc1)S(C)(=O)=O
• Target: Cytochromes P450,Autophagy,mTOR,PI3K
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.39 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:22 mg/mL (48.3 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  DNA-PK:8.831 μM|mTOR:9.9 nM
• In Vivo:
  In vitro, XL388 inhibited the activity of solid and hematopoietic tumor cell lines as well as the proliferation of MCF-7 cell line (IC50: 1.37 μM). xL388 inhibited mTORC1 phosphorylation of p70S6K (T389) in MCF-7 cells (IC50: 94 nM). xL388 inhibited the phosphorylation of mTORC2 by AKT (S473) (IC50 : 350 nM).
• In Vitro:
  In vitro, XL388 inhibited the activity of solid and hematopoietic tumor cell lines as well as the proliferation of MCF-7 cell line (IC50: 1.37 μM). xL388 inhibited mTORC1 phosphorylation of p70S6K (T389) in MCF-7 cells (IC50: 94 nM). xL388 inhibited the phosphorylation of mTORC2 by AKT (S473) (IC50 : 350 nM).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CYP2C9, Mammalian target of Rapamycin, Inhibitor, inhibit, mTORC2, mTORC1, mTOR, XL 388, XL-388, XL388, PI3Kα

Compound Identifiers

PubChem CID

59604787