XL092

SKU: orb1298409

Description

XL092 (JUN04542) is a small molecule inhibitor targeting Axl, Mer, and c-Met receptor tyrosine kinases. It is a research tool for studying cancers dependent on these pathways and has demonstrated activity in preclinical in vitro and in vivo models of tumor growth and metastasis.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 2367004-54-2
• MW: 528.53
• Purity: 99.51%
• Formula: C₂₉H₂₅FN₄O₅
• SMILES: CNC(=O)c1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)ccnc2cc1OC
• Target: TAM Receptor,c-Met/HGFR,VEGFR
• Solubility: DMSO:5.29 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  MET:15 nM (IC50)|Mer:7.2 nM (IC50)|Axl:3.4 nM (IC50)|VEGFR2:1.6 nM (IC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CL092, CL-092, CL 092, cMet/HGFR, c-Met/HGFR, cMet, c-Met, Axl, ATP, inhibit, KDR, JUN04542, JUN-04542, JUN 04542, orally, p-MET, Inhibitor, HGFR, Mer, TAM Receptor, TAMReceptor, p-VEGFR2, XL 092, XL-092, XL092, Tyro3, Vascular endothelial growth factor receptor, VEGFR

Compound Identifiers

PubChem CID

139350422